|
KMID : 0043320130360111338
|
|
Archives of Pharmacal Research
2013 Volume.36 No. 11 p.1338 ~ p.1344
|
|
|
Synthesis and negative inotropic effects evaluation of 7-substituted-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones
|
|
Hong Lan
Gong Guo Hua
Yu Li
Song Ming Xia
Cui Xun
Quan Zhe Shan
|
|
|
Abstract
|
|
|
|
A series of 7-alkoxy-4,5-dihydro-[1,2,4]oxadiazolo[4,3-a]quinolin-1-ones was synthesized and their negative inotropic effects were evaluated by measuring the left atrium stroke volume in isolated rabbit heart preparations. All compounds moderated the cardiac workload by decreasing heart rate and contractility (inotropic effects). Among them, compound 6 was found to be best potent with a ?28.89 ± 1.91 % decrease in the stroke volume at a concentration of 3 × 10?5 M in our in vitro study.
|
|
|
KEYWORD
|
|
|
Oxadiazolo[4, 3-a]quinolin-1-one, Negative inotropic activity, Stroke volume
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|